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Cushing’s Disease Treatment

Treatment for Cushing’s disease is generally not immediately started by vets if the dogs results are positive for these above mentioned tests. Vets administer the treatments only when the pets show symptoms of the disease or if owners insist on improving the lifestyle of their furry friends. Some of the medications used to treat this disease may have serious side effects. The treatment procedures adopted by the vet usually depends on the type of Cushing’s disease the dog is suffering from.

Surgery is used as a treatment option for dogs suffering from adrenal dependent Cushing’s disease. Adrenal tumors can be surgically resectioned due to their comparatively larger size and uncomplicated placement. In this process, both the tumor and the affected adrenal gland are removed and the tumor never affects the other unharmed adrenal gland. However; the surgery can often become more complicated, as most dogs diagnosed with Cushing’s disease are elderly and may fail to survive the risks. Moreover, dogs that are surgically treated are administered prednisone throughout their life.
Surgery is not generally used as a treatment for pituitary dependent Cushing’s disease, as pituitary tumors or adenomas tend to be very small in size and their complicated placement just below the brain makes it increasingly difficult for the vet to surgically resection the gland. Moreover, pituitary tumors are very slow-growing and rarely lead to any deadly effects even when left untreated. Pituitary dependent Cushing’s disease is therefore mostly treated with medications.

Although surgery may sound as an effective treatment, it is generally avoided due to the associated side effects. Mentioned below are some medications used to treat Cushing’s disease in dogs:

1.  Lysodren or Mitotane
Mitotane is the generic name for lysodren medication. This is one of the most popular and oldest drugs that have been in use to treat Cushing’s disease. This is also one of the cheapest drugs available for the same. Lysodren can effectively control the symptoms of Cushing’s disease. However, this drug can lead to serious complications in the patient like vomiting, incoordination, anorexia (lack of interest in eating), lethargy, weakness and diarrhea.

Lysodren acts by gradually thinning and destroying the second and third layer of adrenal cortex, as these are the regions which are mostly responsible for the excessive production of cortisol. This drug should be ideally given with food, as fat enhances the absorption of the medicine. Dogs administered with lysodren should be closely monitored for side effects, so that the vet can change the medicine or alter the dosage as needed.

2.  Ketoconazole
Ketoconazole is an anti-fungal medicine, which is mostly used when other medications used to treat Cushing’s disease lead to extremely serious side effects. This medicine can be administered for both pituitary dependent and adrenal dependent Cushing’s disease. However, the benefits of this drug have been found to be temporary. The dosage of this medication is generally increased after closely monitoring the dog for a week. If the dog doesn’t display any serious side effects like anorexia and vomiting, the dosage is increased.

3.  Trilostane
Trilostane is a new entry into the world of drug market for treating Cushing’s disease. Although trilostane works in almost the same way as lysodren, it has been found to have fewer side effects than lysodren. This drug works by inhibiting the activities of an enzyme called 3-beta-hydroxysteroid dehydrogenase, which is associated with stimulating the production of various steroids, including cortisol. This drug is more expensive than lysodren and is now the mostly used drug to treat Cushing’s disease.

4.  L-Deprenyl
L-Deprenyl or Anipryl is used only to treat pituitary dependent Cushing’s disease. This drug is generally used as an alternative of lysodren, as it has been found to possess lesser side effects as compared to lysodren. L-Deprenyl works by enhancing the levels of dopamine, a type of neurotransmitter that signals the pituitary gland to produce ACTH. When dopamine levels in pituitary gland and brain is high, the pituitary gland stops secreting ACTH, which in turn stops the secretion of cortisol from the adrenal glands. Probable side effects related to this medicine are occasional hearing loss, restlessness, digestive problems and disorientation.

5.  Radiation
Just like treating human cancer, radiation is also used to treat pituitary tumors. This treatment option is generally used if the tumor becomes extremely large and spread to the other parts of the brain. However, this treatment option is generally avoided as it has many associated side effects and some dogs may even fail to bear the pain of undergoing this treatment. An MRI is carried out before proceeding with the therapy. With this treatment, the symptoms vanish. However, in real case the tumor shrinks but doesn’t disappears.

Other medications
Apart from the above mentioned maledictions, physicians and vets sometime prescribe other medications to deal with the symptoms the dogs exhibit.

Cabergoline is a drug which acts in almost the same way as L-Deprenyl. Although this drug has been mostly used for human patients, it has been found to be effective for more than 40% of the cases involving Cushingoid dogs. This drug is a dopamine receptor agonist and acts in the same way to stop cortisol production as L-Deprenyl. Although Cabergoline has shown effective results as a long term treatment therapy, the patient is needed to be observed closely for side effects and dosage alterations. Despite its effectiveness, this drug can only be used to treat pituitary dependent Cushing’s disease.

Retinoic acid
Retinoic acid is thought to be a boon for Cushing’s disease patients. A clinical study where dogs were administered with retinoic acid for 180 days revealed that most of the signs and symptoms initially exhibited by the dogs were suppressed and their condition improved considerably. Their cortisol:creatinine urine ratio and other clinical signs and symptoms improved during the study. Retinoic acid is a compound which is similar to vitamin A and its regular administration improves the signs of Cushing’s disease in dogs. However, excessive use of retinoic acid should be avoided, as it is toxic in excessive amount and recommendation of the vet is inevitable for the administration of this drug.

Alternative treatments for Cushing’s

Cushing’s disease can also be treated with several homeopathic medications. Although the results may never be as quick as the more traditional medications they are usually much healthier for your dog in the long run. However, some homeopathic medications would never be able to cure the root cause, the dog will probably not have to suffer from the innumerable side effects associated with Cushing’s disease meds. Some of the effective homeopathic medicines for this disease are Mercurius for treating diarrhea, irritability, bladder infection and thirst. Arsenicum for excessive thirst and urination rate (polyuria). Sulphur for reducing thirst, improving digestion and skin allergies. Last but not the least; Hepa Sulph is used for healing wounds and infections.

Some herbs like dandelion, astragalus and burdock can be used to normalize adrenal, kidney and liver functions. These herbs also detoxify the body, normalize blood sugar levels, strengthen the immune system, soothe irritated skin and regulate blood pressure levels, thereby providing an all-round therapy to the patient.

Lignans are plant antioxidants and estrogens, which when administered regularly to Cushingoid pets, reduce the levels of steroid and male and female hormones. Lignans’ effectiveness in treating Cushing’s disease has also been scientifically established. However, no controlled measures of administering lignans have been formulated.

Holistic drops
A few companies have evolved, who are manufacturing, or rather to be precise, tailor making special holistic drops to prevent and treat the symptoms of Cushing’s disease. These drops address most of the symptoms of Cushing’s disease and some are tailor made to meet the requirements of each dog. Some of these premium quality drops provide duration guarantee to improve the symptoms of Cushing’s disease. Being formulated with herbs and homeopathy medicines, these drops are completely safe for use and should be used if you want to avoid the side effects of medications, yet bring about faster improvements in your dog’s condition. One such natural medication which is has been proven to be the best in the industry is Cushalin.

Cushalin is the best alternative medicine available on the market for dogs suffering from Cushing’s disease. It is completely natural and is formulated with the highest quality and pharmaceutical grade herbs and other ingredients. The fact that Cushalin is completely herbal makes it completely safe for dogs and no matter what type of Cushing’s disease your dog is suffering from, Cushalin’s beneficial properties will help!

Other than being made of completely natural ingredients, every bottle of Cushalin is tailor made to suit the specific and different needs of each and every dog. This is because, not all dogs suffering from Cushing’s disease exhibit the same symptoms and hence, their requirements are also different. We therefore make it a point to formulate every bottle differently and according to the requirements of your dog and the exact symptoms you want to manage. Moreover, every bottle of the Cushalin is scientifically formulated, with ingredients which have been clinically proven to show results without the use of any harmful effects found in prescription medications.

Every bottle of Cushalin comes with a No Question Asked Money Back Guarantee. Whats-more, the is completely natural and tailor made, making it far safer than a majority of Cushing’s medications prescribed by doctors. The ingredients have been independently tested and guaranteed to manage most of the symptoms of the disease.

Hence, if you truly love your dog and is ready to do anything to provide him or her with a better quality of life, make sure that you try Cushalin. Moreover, with Cushalin’s money back guarantee, you don’t have to risk a single penny of yours for your dog’s life and health. Please visit our HomePage and learn why thousands of dog owners turn to Cushalin to help their dogs fight this disease.

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An Article By -

Dogs Love It Natural | We believe that certain canine diseases can be treated and/or managed far better using all-natural ingredients then any similar prescription medication. Research has shown that the side effects of some prescriptions may be more harmful then the disease itself – Cushing’s Disease being at the top of this list!

Cushalin has successfully been used to help manage the symptoms of Cushing’s since 2008. If you have any questions, please don’t hesitate to contact us.

Thank You,
Holistic Doggie

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