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Cushing’s Disease Medications and Side Effects

Cushing’s disease is a serious life threatening disease commonly found in older dogs. This disease although mostly common in certain breeds, can affect all dog breeds. Cushing’s disease greatly reduces the life expectancy of a dog and can also prove to be fatal when not treated in time. Some owners even fail to spot the correct problem in their dogs and while in the process of diagnosis, their furry friends often fail to bear the problem. However; once the disease is diagnosed, it can be successfully treated with surgery and medications. Although these medications have proven to be beneficial for the patient dogs, just as with any other types of medications, medications used to treat Cushing’s disease have also been found to possess side effects. Though the side effects are never life threatening, they can put your pet under pressing circumstances. Mentioned below are some common side effects you may notice in your dog if he/she is prescribed certain Cushing’s disease medications.

Digestive side effects

Indigestion, vomiting, diarrhea and loss of appetite are common side effects observed in pets who are put under Cushing’s disease medications. These side effects are common with all types of medications used to treat Cushing’s disease, including Lysodren, Trilostane and Ketoconazole. While Trilostane has been proven to possess least side effects as compared to Lysodren, you should check your pet for digestive disorders when under Trilostane administration and inform your vet as soon as possible, so that you vet can take appropriate measures.


Nausea is yet another side effects of L-Deprenyl. Dogs may display signs of nausea when under the treatment of this drug.

Lack of coordination

Lack of coordination is a very common side effect of Cushing’s disease prescribed medications, especially Lysodren and Ketoconazole. Your dog may display lethargic attitude and lose interest in moving around or playing unlike before.


All these drugs, except Trilostane should be strictly avoided for stud and pregnant dogs. Your dog run thew risk of becoming sterile or undergoing abortion when treated with these drugs.

Liver damage

Drugs like Ketoconazole can impose a serious threat to your dog’s liver when used for a prolonged duration. Your dog will show signs of liver damage in the form of yellowing of teeth and fatigue so be aware of this and check your dog often.

Coat color discharge

Dogs who are being treated with ketoconazole may initially display a loss of coat color, which means that their coat color will turn lighter than normal. The color generally returns to the original shade after a few days of the drug’s administration.

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Dogs Love It Natural | We believe that certain canine diseases can be treated and/or managed far better using all-natural ingredients then any similar prescription medication. Research has shown that the side effects of some prescriptions may be more harmful then the disease itself – Cushing’s Disease being at the top of this list!

Cushalin has successfully been used to help manage the symptoms of Cushing’s since 2008. If you have any questions, please don’t hesitate to contact us.

Thank You,
Holistic Doggie

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